Transcriptional Regulation of the ATP Citrate-lyase Gene by Sterol Regulatory Element-binding Proteins
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of the ATP citrate-lyase gene by sterol regulatory element-binding proteins.
In an attempt to identify unknown target genes for SREBP-1, total RNA from a stable Chinese hamster ovary cell line (CHO-487) expressing a mature form of human SREBP-1a (amino acids 1-487) with a LacSwitch Inducible Mammalian Expression System was subjected to a polymerase chain reaction subtraction method. One of the fragments was found to have 90 and 86% homology with rat and human ATP citrat...
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Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of ...
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In the process of membrane biogenesis several dozen proteins must operate in precise concert to generate approximately 100 lipids at appropriate concentrations. To study the regulation of bilayer assembly in a cell cycle-independent manner, we have exploited the fact that phagocytes replenish membranes expended during particle engulfment in a rapid phase of lipid synthesis. In response to phago...
متن کاملRegulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms.
The synthesis of phosphatidylcholine (PtdCho) by the CDP-choline pathway is under the control of the rate-limiting enzyme CTP:phosphocholine cytidylyltransferase (CCT). Sterol regulatory element binding proteins (SREBPs) have been proposed to regulate CCT at the transcriptional level, or via the synthesis of lipid activators or substrates of the CDP-choline pathway. To assess the contributions ...
متن کاملRegulation of the Rat Phospholipid Translocase Mdr2 Gene Expression by Cholesterol Synthesis Inhibitors and Sterol Regulatory Element-binding Proteins
We have been shown in rats that the hepatic expression of the phosphatidylcholine translocase Mdr2 is induced by statins, inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Statins are known to activate sterol regulatory element-binding proteins (SREBPs), transcription factors that control key enzymes of the cholesterol and fatty acid biosynthetic pathways. Here, we investigated the...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.17.12497